Nerve and circulatory damage from high blood sugars and high blood pressure, known as peripheral neuropathy, can affect the feet or hands. This can make feet less able to feel pain, heat or cold or make them more sensitive to pain or touch. Dry or cracking skin and open wounds can become more common and heal less quickly, increasing the risk of becoming infected. If an infection develops and is not treated, removal (amputation) may be required. In fact, diabetes is the leading cause of non-traumatic lower-limb amputation in our country.